When he left Tennessee, Peyton held 42 NCAA, SEC and Tennessee records, including 33 Tennessee single game, season and career records.

NCAA Records (2)  
  Single Season Lowest Interception Percentage 1.05%; 4 of 380 attempts in 1995
  Career Lowest Interception Percentage 2.39%; 33 of 1.381 attempts
SEC Records (7)  
  Single Season Lowest Interception Percentage 1.05%; 4 of 380 attempts in 1995
  Career Passing Yards 11,201
  Completions 863
  Total Offense 11,020
  Completion Percentage 62.49%; 863 of 1,381
  Lowest Interception Percentage 2.39%; 33 of 1.381 attempts
  Most 300 Yard Passing Games 18
Tennessee Records (33)  
Single Game (7)  
  Most TD Passes 5; Texas Tech & Kentucky, 1997
  Most Passing Yards 523; Kentucky, 1997
  Most Pass Attempts 65; Florida, 1996
  Most Pass Completions 37; Florida, 1996
  Most Total Offense Plays 70; Florida, 1996
  Most Total Offensive Yards 508; Kentucky, 1997
  Consecutive Pass Completions 12; Kentucky, 1997
Season (10)  
  Most Passing Yards 3,819 in 1997
  Most Passing Touchdowns 36 in 1997
  Most Pass Attempts 477 in 1997
  Most Pass Completions 287 in 1997
  Highest Completion Percentage 64.2 in 1995 (minimum 300 attempts)
  Lowest Interception Percentage 1.05 in 1995; 4 of 380
  Consecutive Passes w/o Interception 132
  Most 300 Yard Passing Games 9 in 1997
  Most Total Offensive Yards 3,789 in 1997
  Most Total Offensive Plays 538 in 1997
Career (16)  
  Most Touchdown Passes 89
  Most Touchdowns Responsible For 101; 89 passing, 12 rushing
  Most 500 Yard Passing Games 1
  Most 400 Yard Passing Games 3
  Most 300 Yard Passing Games 18
  Most 200 Yard Passing Games 30
  Consecutive 300 Yard Passing Games 7
  Most Passing Yards 11,201
  Most Pass Attempts 1,381
  Most Pass Completions 863
  Highest Completion Percentage 62.49%
  Lowest Interception Percentage 3.29%
  Most Total Offense Yards 11,020
  Most Total Offense Plays 1,534
  Most Offense Yards Per Game 250.5; 44 for 11,020
  Most Yards Per Play 7.18; 1,534 for 11,020